The Fischbein Laboratory in the Stanford University Department of Cardiothoracic Surgery is seeking to hire a full-time Life Science Research Professional 1 in our lab. We focus on investigating the molecular mechanisms of aortic aneurysm formation in Marfan Syndrome, a genetic connective tissue disorder. We use a combination of human tissue/cells, transgenic mouse models, and induced pluripotent stem cells to identify aberrant signaling pathways through single cell RNA sequencing, mass spectroscopy proteomics, and histology. Please see recent publication for an example of our prior work with single cell RNA sequencing and mass spectroscopy:
https://pubmed-ncbi-nlm-nih-gov.laneproxy.stanford.edu/32698686/
https://pubmed-ncbi-nlm-nih-gov.laneproxy.stanford.edu/33230159/
https://doi.org/10.1161/HYPERTENSIONAHA.121.18640
Responsibilities include: mouse husbandry and genotyping, imaging studies such as echocardiogram, confocal microscopy, atomic force microscopy; assisting in small animal cardiac surgery; Rstudio and ImageJ analysis; and cell culture. Lab members will have the opportunity to take a leadership role on a project with the goal of contributing to manuscript writing and grant proposals. The lab is a very dynamic environment where lab members can take full advantage of the myriad of resources present at a leading academic institution. The setting is ideal for very motivated individuals who desire an active role in a biomedical research lab, while concurrently acquiring exposure to clinical medicine.
Ideally, we are looking for a minimum 2-year commitment for this position, but this can be somewhat flexible depending on individual qualifications and circumstance. We are also looking to fill this position as soon as possible, potentially starting as early as July 2022.
Duties include:
- Plan approach to experiments in support of research projects in lab and/or field based on knowledge of scientific theory.
- Independently conduct experiments; maintain detailed records of experiments and outcomes.
- Apply the theories and methods of a life science discipline to interpret and perform analyses of experiment results; offer suggestions regarding modifications to procedures and protocols in collaboration with senior researcher.
- Review literature on an ongoing basis to remain current with new procedures and apply learnings to related research.
- Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.
- Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed.
- Assist with orientation and training of new staff or students on lab procedures or techniques.
*- Other duties may also be assigned.
DESIRED QUALIFICATIONS :
- A degree in biology, chemistry, biochemistry, biomedical engineering.
- Basic science experience desired, but ability for on the job learning to perform experiments is more important.
- Experience with Rstudio or other CS experience, excel and ImageJ.
- Knowledge (or interest) of cardiovascular/cardiopulmonary anatomy & physiology.
EDUCATION & EXPERIENCE (REQUIRED):
- Bachelor's degree in related scientific field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
- General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
- Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
- Ability to maintain detailed records of experiments and outcomes.
- General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
- Ability to work under deadlines with general guidance.
- Excellent organizational skills and demonstrated ability to accurately complete detailed work.
PHYSICAL REQUIREMENTS*:
- Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
- Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
- Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
- Must have correctible vision to perform duties of the job.
- Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
- Ability to lift heavy objects weighing up to 50 pounds.
- Ability to work in a dusty, dirty, and odorous environment.
- Position may require repetitive motion.
*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
WORKING CONDITIONS:
- May require working in close proximity to blood borne pathogens.
- May require work in an environment where animals are used for teaching and research.
- Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
- Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
- May require extended or unusual work hours based on research requirements and business needs.
WORK STANDARDS:
- Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
- Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
- Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.
As an organization that receives federal funding, Stanford University has a COVID-19 vaccination requirement that will apply to all university employees, including those working remotely in the United States and applicable subcontractors. To learn more about COVID policies and guidelines for Stanford University Staff, please visit https://cardinalatwork.stanford.edu/working-stanford/covid-19/interim-policies/covid-19-surveillance-testing-policy.
